Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans

Summary Deletions in mitochondrial DNA (mtDNA) accumulate during aging. Expression of the Caenorhabditis elegans apurinic/apyrimidinic endonuclease 1 (APE1) ortholog exo‐3, involved in DNA repair, is reduced by 45% (P

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Aging cell 2010-06, Vol.9 (3), p.420-432
Hauptverfasser:	Schlotterer, Andreas, Hamann, Andreas, Kukudov, Georgi, Ibrahim, Youssef, Heckmann, Britta, Bozorgmehr, Farastuk, Pfeiffer, Michael, Hutter, Harald, Stern, David, Du, Xueliang, Brownlee, Michael, Bierhaus, Angelika, Nawroth, Peter, Morcos, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals C. elegans Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism DNA repair DNA, Mitochondrial - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Gene Deletion mitochondrial DNA p53 reactive oxygen species Reactive Oxygen Species - metabolism RNA Interference Thioredoxins - genetics Thioredoxins - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Deletions in mitochondrial DNA (mtDNA) accumulate during aging. Expression of the Caenorhabditis elegans apurinic/apyrimidinic endonuclease 1 (APE1) ortholog exo‐3, involved in DNA repair, is reduced by 45% (P
ISSN:	1474-9718 1474-9726
DOI:	10.1111/j.1474-9726.2010.00572.x