Cytotoxic Grifolin Derivatives Isolated from the Wild Mushroom Boletus pseudocalopus (Basidiomycetes)
Activity‐guided purification of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus afforded three new grifolin derivatives, 1–3, along with four known phenolic compounds 4–7. Their structures were established by a combination of 1H‐ and 13C‐NMR, NOESY, and extensive two‐dimensional NMR...
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Veröffentlicht in: | Chemistry & biodiversity 2009-09, Vol.6 (9), p.1435-1442 |
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Sprache: | eng |
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Zusammenfassung: | Activity‐guided purification of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus afforded three new grifolin derivatives, 1–3, along with four known phenolic compounds 4–7. Their structures were established by a combination of 1H‐ and 13C‐NMR, NOESY, and extensive two‐dimensional NMR spectroscopic experiments such as gCOSY, gHSQC, gHMBC, and ROESY. The major metabolites 4 and 5 were subjected to reduction to provide the side chain‐reduced compounds 8 and 9 for biological testing. All of the compounds except compound 6 showed anticancer activities in the range of IC50 3.5–11.0 μg/ml against human lung carcinoma A549 and mouse melanoma B16F1 cell lines. In addition, all compounds showed moderate radical‐scavenging activities determined by DPPH assay. |
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ISSN: | 1612-1872 1612-1880 |
DOI: | 10.1002/cbdv.200800217 |