Quinazolines and 1,4-benzodiazepines LXXXIX: Haptens useful in benzodiazepine immunoassay development

The syntheses of some 1,4-benzodiazepines potentially useful as haptens are reported. These compounds are related to chlordiazepoxide, diazepam, nitrazepam, clonazepam, and some of their metabolites. The chemistry reported here is intended to support specific immunoassay development for these drugs.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1979-07, Vol.68 (7), p.845-850
Hauptverfasser:	Earley, James V., Fryer, R.Ian, Ning, Robert Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzodiazepines - analysis Benzodiazepines - chemical synthesis Benzodiazepines - immunology Benzodiazepines—chemical synthesis, potentially useful haptens Chemical Phenomena chemical synthesis Chemistry Haptens - chemical synthesis Haptens-benzodiazepines Haptens—benzodiazepines, chemical synthesis potentially useful haptens Radioimmunoassay Tranquilizers-benzodiazepines Tranquilizers—benzodiazepines, various, chemical synthesis, potentially useful haptens various
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Beschreibung
Zusammenfassung:	The syntheses of some 1,4-benzodiazepines potentially useful as haptens are reported. These compounds are related to chlordiazepoxide, diazepam, nitrazepam, clonazepam, and some of their metabolites. The chemistry reported here is intended to support specific immunoassay development for these drugs.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600680715