The immunobiology of CD154–CD40–TRAF interactions in atherosclerosis

Abstract Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-sti...

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Veröffentlicht in:	Seminars in immunology 2009-10, Vol.21 (5), p.308-312
Hauptverfasser:	Engel, David, Seijkens, Tom, Poggi, Marjorie, Sanati, Maryam, Thevissen, Larissa, Beckers, Linda, Wijnands, Erwin, Lievens, Dirk, Lutgens, Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Atherosclerosis Atherosclerosis - immunology CD154 CD40 CD40 Antigens - immunology CD40 Ligand - immunology Co-stimulation Humans Inflammation Signal Transduction - immunology Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - immunology
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Beschreibung
Zusammenfassung:	Abstract Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand , CD40L)–CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.
ISSN:	1044-5323 1096-3618
DOI:	10.1016/j.smim.2009.06.004