Research status and application progression in periodontal locally sustained-release antimicrobials

BACKGROUND: Local application of sustained-release antimicrobials serve as an adjuvant therapy of periodontitis, and the dosage form, medicine and carrier material have greatly developed. OBJECTIVE: To summarize the current situation and progression of periodontal local sustained-release antimicrobials at home and abroad. METHODS: A computer-based online search of CNKI and Pubmed (1999-01/2009-10) was performed for the related articles about sustained-release antimicrobials, with the key words "periodontitis, treatment, medication, and sustained-release". The articles in the same field published recently or in authoritative journals were selected. A total of 143 articles were collected, and 40 related sustained-release antimicrobials were included. RESULTS AND CONCLUSION: Application of sustained-release antimicrobials is a well adjuvant therapy for some special clinical periodontitis. It is widely used due to its low dosage, long lasting-time and well target effect. The clinical application of sustained-release antimicrobials is promising along with the development of compound medicine and periodontal tissue regeneration.