Structure of the Fc fragment of human lgE bound to its high-affinity receptor FcepsilonRlalpha
The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, FCERI. Crosslinking of FCERI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response.
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| Veröffentlicht in: | Nature (London) 2000-07, Vol.406 (6793), p.259-266 |
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| container_end_page | 266 |
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| container_issue | 6793 |
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| container_title | Nature (London) |
| container_volume | 406 |
| creator | Garman, Scott C Wurzburg, Beth A Tarchevskaya, Svetlana S Kinet, Jean-Pierre Jardetzky, Theodore S |
| description | The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, FCERI. Crosslinking of FCERI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. |
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| ispartof | Nature (London), 2000-07, Vol.406 (6793), p.259-266 |
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| source | Nature; SpringerNature Journals |
| subjects | Allergies Biochemistry Cells Cellular biology Crystallography |
| title | Structure of the Fc fragment of human lgE bound to its high-affinity receptor FcepsilonRlalpha |
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