Structure of the Fc fragment of human lgE bound to its high-affinity receptor FcepsilonRlalpha

Structure of the Fc fragment of human lgE bound to its high-affinity receptor FcepsilonRlalpha

The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, FCERI. Crosslinking of FCERI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response.

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Veröffentlicht in:Nature (London) 2000-07, Vol.406 (6793), p.259-266
Hauptverfasser: Garman, Scott C, Wurzburg, Beth A, Tarchevskaya, Svetlana S, Kinet, Jean-Pierre, Jardetzky, Theodore S
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Biochemistry
Cells
Cellular biology
Crystallography
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Zusammenfassung:The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, FCERI. Crosslinking of FCERI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response.
ISSN:0028-0836
1476-4687