Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine

Atrazine is an herbicide considered as a potent endocrine disruptor, causing adverse effects on both gender of mammalian and non-mammalian species. Despite the known adverse effects of Atrazine, little is known about its action on male genital system, especially in adults. We evaluated the effects o...

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Veröffentlicht in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2010-06, Vol.29 (3), p.323-331
Hauptverfasser: Victor-Costa, Anna Bolivar, Bandeira, Simone Miranda Carozzi, Oliveira, André Gustavo, Mahecha, Germán Arturo Bohórquez, Oliveira, Cleida Aparecida
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Sprache:eng
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Zusammenfassung:Atrazine is an herbicide considered as a potent endocrine disruptor, causing adverse effects on both gender of mammalian and non-mammalian species. Despite the known adverse effects of Atrazine, little is known about its action on male genital system, especially in adults. We evaluated the effects of Atrazine (50 mg/kg, 200 mg/kg and 300 mg/kg) in the 3β-hydroxysteroid dehydrogenase (3β-HSD) expression, plasmatic and testicular estrogen and testosterone levels, androgen receptor expression and morphological changes in adult rat testes. Atrazine at doses higher than 50 mg/kg resulted in decreased body weight, increased adrenal weight and transient increase in testis weight, followed by testis atrophy. A reduction in testosterone but increase in estradiol levels was observed. We showed for the first time that testicular 3β-HSD protein was decreased, whereas in the adrenal it was unchanged. The results suggest that 3β-HSD inhibition may represent an alternative mechanism through which Atrazine affects the testicular androgenesis, leading to changes in spermatogenesis.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2009.12.006