Design and Synthesis of Novel UDP-Mur-NAc, UDP-Mur-NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu mimetics

Design and Synthesis of Novel UDP-Mur-NAc, UDP-Mur-NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu mimetics

A series of novel phenylsulfonylcarbamates were designed and synthesized as mimetics of UDP-Mur-NAc, UDP-Mur-NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu with the potential to inhibit ATP-dependent amide-forming ligases Mur- B, C, D and E, involved in the biosynthesis of bacterial cell wall. A detailed syn...

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Veröffentlicht in:Acta chimica Slovenica 2009-01, Vol.56 (3)
Hauptverfasser: Frlan, R, Perdih, F, Cirkvencic, N, Pecar, S, Obreza, A
Format: Artikel
Sprache:eng
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Zusammenfassung:A series of novel phenylsulfonylcarbamates were designed and synthesized as mimetics of UDP-Mur-NAc, UDP-Mur-NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu with the potential to inhibit ATP-dependent amide-forming ligases Mur- B, C, D and E, involved in the biosynthesis of bacterial cell wall. A detailed synthesis of these compounds is presented.
ISSN:1318-0207