The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antivir...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-03, Vol.20 (6), p.1994-2000
Hauptverfasser:	TANIS, Steven P, STROHBACH, Joseph W, STEPHANSKI, Kevin J, WATHEN, Michael W, PARKER, Timothy T, MOON, Malcom W, THAISRIVONGS, Suvit, PERRAULT, William R, HOPKINS, Todd A, KNECHTEL, Mary L, OIEN, Nancee L, WIEBER, Janet L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Drug Design Human cytomegalovirus Medical sciences Pharmacology. Drug treatments Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Quinoxalines - chemistry Quinoxalines - pharmacology Serine Endopeptidases - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antiviral activity of various 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2010.01.094