The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation

Background. The aim of this study was to examine the development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation in relation to the Banff 07 histological classification. Methods. Renal biopsies were scored using the Banff 07 diagnostic criteria, and paraffin-e...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2010-04, Vol.25 (4), p.1306-1312
Hauptverfasser:	Higgins, Rob, Zehnder, Daniel, Chen, Klaus, Lowe, David, McKinnell, Joanna, Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, Chris, Fletcher, Simon, Krishnan, Nithya, Hamer, Rizwan, Briggs, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy antibody-incompatible transplantation Biological and medical sciences CD20 Complement C4b - immunology complement C4d Emergency and intensive care: renal failure. Dialysis management Female Graft Rejection - immunology Graft Rejection - pathology HLA antibodies HLA Antigens - immunology Humans Immunoglobulin G - immunology Intensive care medicine Kidney Diseases - therapy Kidney Transplantation - immunology Kidney Transplantation - pathology Male Medical sciences Middle Aged Peptide Fragments - immunology renal allograft histology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Young Adult
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Zusammenfassung:	Background. The aim of this study was to examine the development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation in relation to the Banff 07 histological classification. Methods. Renal biopsies were scored using the Banff 07 diagnostic criteria, and paraffin-embedded sections were stained with the pan-leucocyte marker CD45. Results. Thirty-six patients had 72 renal biopsies. In biopsies performed 30 min after graft reperfusion, the mean number of CD45+ cells per glomerulus was higher than in control grafts (P
ISSN:	0931-0509 1460-2385
DOI:	10.1093/ndt/gfp610