CagA and VacA Polymorphisms Are Associated with Distinct Pathological Features in Helicobacter pylori-Infected Adults with Peptic Ulcer and Non-Peptic Ulcer Disease

Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of th...

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Veröffentlicht in:	Journal of Clinical Microbiology 2010-06, Vol.48 (6), p.2237-2239
Hauptverfasser:	Panayotopoulou, Effrosini G, Sgouras, Dionyssios N, Papadakos, Konstantinos S, Petraki, Kalliopi, Breurec, Sébastien, Michopoulos, Spyros, Mantzaris, Gerassimos, Papatheodoridis, George, Mentis, Andreas, Archimandritis, Athanasios
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Bacterial Antigens, Bacterial - genetics Bacterial Proteins Bacterial Proteins - genetics Bacteriology Biological and medical sciences DNA, Bacterial DNA, Bacterial - chemistry DNA, Bacterial - genetics Female Fundamental and applied biological sciences. Psychology Helicobacter Infections Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - isolation & purification Helicobacter pylori - pathogenicity Humans Life Sciences Male Microbiology Microbiology and Parasitology Middle Aged Miscellaneous Molecular Sequence Data Peptic Ulcer Peptic Ulcer - microbiology Polymorphism, Genetic Sequence Analysis, DNA Severity of Illness Index Virulence Factors Virulence Factors - genetics
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Zusammenfassung:	Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00662-10