Enhancement of antitumor immune response by targeted interleukin-12 electrogene transfer through antiHER2 single-chain antibody in a murine bladder tumor model

Abstract Interleukin-12 (IL-12), despite exerting antitumor activity, has limited therapeutic uses due to its systemic toxicity. Since HER2 (also known as ErbB-2, neu, and HER2/neu) is frequently overexpressed on cancer cells, HER2-targeted delivery of IL-12 to tumors may be a promising strategy for...

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Veröffentlicht in:Vaccine 2009-08, Vol.27 (39), p.5383-5392
Hauptverfasser: Tsai, Yuh-Shyan, Shiau, Ai-Li, Chen, Yu-Fon, Tsai, Hsin-Tzu, Lee, Hwei-Ling, Tzai, Tzong-Shin, Wu, Chao-Liang
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Sprache:eng
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