Iodinated Nanoscale Coordination Polymers as Potential Contrast Agents for Computed Tomography

Iodinated Nanoscale Coordination Polymers as Potential Contrast Agents for Computed Tomography

Nanoscale coordination polymers (NCPs), prepared with metal ions and an iodinated ligand, were synthesized using reverse‐phase microemulsion techniques and rapid precipitation procedures. The NCPs carry high payloads of iodine (ca. 63 wt %) and have potential applications as a new class of contrast...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-12, Vol.48 (52), p.9901-9904
Hauptverfasser: deKrafft, Kathryn E, Xie, Zhigang, Cao, Guohua, Tran, Sylvie, Ma, Liqing, Zhou, Otto Z, Lin, Wenbin
Format: Artikel
Sprache:eng
Schlagworte:
computed tomography
contrast agents
Contrast Media - chemistry
coordination polymers
Crystallography, X-Ray
iodine
Iodine - chemistry
Molecular Conformation
nanoparticles
Nanoparticles - chemistry
Polymers - chemistry
Tomography, X-Ray Computed
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Zusammenfassung:Nanoscale coordination polymers (NCPs), prepared with metal ions and an iodinated ligand, were synthesized using reverse‐phase microemulsion techniques and rapid precipitation procedures. The NCPs carry high payloads of iodine (ca. 63 wt %) and have potential applications as a new class of contrast agents for computed tomography (CT), as demonstrated by phantom studies (see figure).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200904958