Preparation of CpG ODN-encapsulated Anionic Poly(amino acid) Nanoparticles for Gene Delivery

Preparation of CpG ODN-encapsulated Anionic Poly(amino acid) Nanoparticles for Gene Delivery

A novel method for preparation of CpG ODN-encapsulated anionic poly(amino acid) nanoparticles (NPs) was developed for gene delivery purposes. CpG ODN was successfully encapsulated into the NPs using self-assembly of amphiphilic poly(amino acid), and the amount of encapsulated CpG ODN was dependent o...

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Veröffentlicht in:Chemistry letters 2010-03, Vol.39 (3), p.278-279
Hauptverfasser: Kim, Hyungjin, Akagi, Takami, Akashi, Mitsuru
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel method for preparation of CpG ODN-encapsulated anionic poly(amino acid) nanoparticles (NPs) was developed for gene delivery purposes. CpG ODN was successfully encapsulated into the NPs using self-assembly of amphiphilic poly(amino acid), and the amount of encapsulated CpG ODN was dependent on the complex ratio of CpG ODN and polycation. The DNA-encapsulated anionic NPs may be useful as a gene delivery and DNA vaccine system with low toxicity.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2010.278