Pentopyranosyl Oligonucleotide Systems, Communication No.12, The b-D-Xylopyranosyl-(4'RT2'-oligonucleotide System

Pentopyranosyl Oligonucleotide Systems, Communication No.12, The b-D-Xylopyranosyl-(4'RT2'-oligonucleotide System

-D-Xylopyranosyl-(42)-oligonucleotides containing adenine and thymine as nucleobases were synthesized as a part of a systematic study of the pairing properties of pentopyranosyl oligonucleotides. Contrary to earlier expectations based on qualitative conformational criteria, -D-xylopyranosyl-(42)-oli...

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Veröffentlicht in:Helvetica chimica acta 2002-02, Vol.85 (2), p.399-416
Hauptverfasser: Wagner, Thomas, Huynh, Hoan K, Krishnamurthy, Ramanarayanan, Eschenmoser, Albert
Format: Artikel
Sprache:eng
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Zusammenfassung:-D-Xylopyranosyl-(42)-oligonucleotides containing adenine and thymine as nucleobases were synthesized as a part of a systematic study of the pairing properties of pentopyranosyl oligonucleotides. Contrary to earlier expectations based on qualitative conformational criteria, -D-xylopyranosyl-(42)-oligonucleotides show Watson-Crick pairing comparable in strength to that shown by pyranosyl-RNA.
ISSN:0018-019X
DOI:10.1002/1522-2675(200202)85:2<399::AID-HLCA399>3.0.CO;2-2