Effects of testosterone replacement in middle-aged men with dysthymia: a randomized, placebo-controlled clinical trial

Mid-life onset male dysthymic disorder (DD) seems to be a distinct clinical condition with limited therapeutic options. Testosterone replacement is mood-enhancing and has been proposed as an antidepressant therapy, though this strategy has received limited systematic study. We therefore conducted a...

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Veröffentlicht in:Journal of clinical psychopharmacology 2009-06, Vol.29 (3), p.216-221
Hauptverfasser: Seidman, Stuart N, Orr, Guy, Raviv, Gil, Levi, Rachel, Roose, Steven P, Kravitz, Efrat, Amiaz, Revital, Weiser, Mark
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Sprache:eng
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Zusammenfassung:Mid-life onset male dysthymic disorder (DD) seems to be a distinct clinical condition with limited therapeutic options. Testosterone replacement is mood-enhancing and has been proposed as an antidepressant therapy, though this strategy has received limited systematic study. We therefore conducted a six-week double-blind placebo-controlled clinical trial in 23 men with DD and with low or low-normal testosterone (T) level (i.e, screening total serum testosterone
ISSN:0271-0749
1533-712X
DOI:10.1097/JCP.0b013e3181a39137