Lipocalin-2: pro- or anti-apoptotic

Survival and apoptosis signaling pathways are altered concomitantly in response to numerous endogenous and exogenous stressors. The lipocalin family of small soluble proteins has been implicated in modulating apoptosis. However, the overall effect of these proteins has been variable, showing both pr...

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Veröffentlicht in:	Cell biology and toxicology 2010-04, Vol.26 (2), p.83-89
1. Verfasser:	Kehrer, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	24p3 Acute-Phase Proteins - antagonists & inhibitors Acute-Phase Proteins - physiology Animals Apoptosis Apoptosis - physiology Biochemistry Biomedical and Life Sciences Cell Biology Cell Survival - physiology Humans Life Sciences Lipocalin-2 Lipocalins - antagonists & inhibitors Lipocalins - physiology Mice Neutrophil gelatinase-associated lipocalin (NGAL) Oncogene Proteins - antagonists & inhibitors Oncogene Proteins - physiology Pharmacology/Toxicology Proteins Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - physiology Signal transduction Signal Transduction - physiology Signaling
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Beschreibung
Zusammenfassung:	Survival and apoptosis signaling pathways are altered concomitantly in response to numerous endogenous and exogenous stressors. The lipocalin family of small soluble proteins has been implicated in modulating apoptosis. However, the overall effect of these proteins has been variable, showing both pro- and anti-apoptotic activities. The goal of this minireview is to summarize the studies on lipocalins and apoptosis and consider what roles lipocalin-2 may play in cell death and survival.
ISSN:	0742-2091 1573-6822
DOI:	10.1007/s10565-009-9119-9