Use of prostaglandin E1 in infants with d-transposition of the great arteries and intact ventricular septum
Prostaglandin E1 was used to treat five infants with d-transposition of the great arteries and intact ventricular septum who had persistent severe hypoxemia after the creation of an interatrial communication. Three infants had a dramatic improvement in systemic arterial oxygen saturation associated...
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Veröffentlicht in: | The American journal of cardiology 1979-07, Vol.44 (1), p.76-81 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Prostaglandin E1 was used to treat five infants with d-transposition of the great arteries and intact ventricular septum who had persistent severe hypoxemia after the creation of an interatrial communication. Three infants had a dramatic improvement in systemic arterial oxygen saturation associated with dilation of the ductus arteriosus; in two of the three cases urgent surgery was avoided. Two infants had no clinical evidence of increased ductal shunting and no improvement in oxygen saturation. A trial of prostaglandin E1 is recommended for treatment of severe hypoxemia in infants with d-transposition of the great arteries with intact ventricular septum if the presence of a large atrial septal defect is established. |
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ISSN: | 0002-9149 |
DOI: | 10.1016/0002-9149(79)90253-4 |