New stilbene dimers against amyloid fibril formation
Two new stilbene dimers could be efficient fibril inhibitors in Alzheimer’s disease: scirpusin A and ε-viniferin glucoside. Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-β peptide (Aβ) aggregation. Results of stilbene monomer derivatives indica...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010-06, Vol.20 (11), p.3441-3443 |
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| creator | Rivière, Céline Papastamoulis, Yorgos Fortin, Pierre-Yves Delchier, Nicolas Andriamanarivo, Soahary Waffo-Teguo, Pierre Kapche, Gilbert D.W.F. Amira-Guebalia, H. Delaunay, Jean-Claude Mérillon, Jean-Michel Richard, Tristan Monti, Jean-Pierre |
| description | Two new stilbene dimers could be efficient fibril inhibitors in Alzheimer’s disease: scirpusin A and ε-viniferin glucoside.
Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-β peptide (Aβ) aggregation. Results of stilbene monomer derivatives indicated that interaction with resveratrol and piceid was specific. Concerning oligomers, scirpusin A and ε-viniferin glucoside demonstrated a strong inhibition of the aggregation process. |
| doi_str_mv | 10.1016/j.bmcl.2009.09.074 |
| format | Article |
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Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-β peptide (Aβ) aggregation. Results of stilbene monomer derivatives indicated that interaction with resveratrol and piceid was specific. Concerning oligomers, scirpusin A and ε-viniferin glucoside demonstrated a strong inhibition of the aggregation process.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2009.09.074</identifier><identifier>PMID: 20452207</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Alzheimer’s disease ; Amyloid - chemistry ; Biological and medical sciences ; Dimerization ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Polyphenol ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Stilbene ; Stilbenes - chemistry ; β-Amyloid peptide</subject><ispartof>Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3441-3443</ispartof><rights>2009</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e2a3a3a307a485a196492c39fafb46f346931f0ea2cb902364ca1d25fb58ec243</citedby><cites>FETCH-LOGICAL-c417t-e2a3a3a307a485a196492c39fafb46f346931f0ea2cb902364ca1d25fb58ec243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X09013420$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22868823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20452207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivière, Céline</creatorcontrib><creatorcontrib>Papastamoulis, Yorgos</creatorcontrib><creatorcontrib>Fortin, Pierre-Yves</creatorcontrib><creatorcontrib>Delchier, Nicolas</creatorcontrib><creatorcontrib>Andriamanarivo, Soahary</creatorcontrib><creatorcontrib>Waffo-Teguo, Pierre</creatorcontrib><creatorcontrib>Kapche, Gilbert D.W.F.</creatorcontrib><creatorcontrib>Amira-Guebalia, H.</creatorcontrib><creatorcontrib>Delaunay, Jean-Claude</creatorcontrib><creatorcontrib>Mérillon, Jean-Michel</creatorcontrib><creatorcontrib>Richard, Tristan</creatorcontrib><creatorcontrib>Monti, Jean-Pierre</creatorcontrib><title>New stilbene dimers against amyloid fibril formation</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Two new stilbene dimers could be efficient fibril inhibitors in Alzheimer’s disease: scirpusin A and ε-viniferin glucoside.
Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-β peptide (Aβ) aggregation. Results of stilbene monomer derivatives indicated that interaction with resveratrol and piceid was specific. Concerning oligomers, scirpusin A and ε-viniferin glucoside demonstrated a strong inhibition of the aggregation process.</description><subject>Alzheimer’s disease</subject><subject>Amyloid - chemistry</subject><subject>Biological and medical sciences</subject><subject>Dimerization</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyphenol</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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| ispartof | Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3441-3443 |
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| subjects | Alzheimer’s disease Amyloid - chemistry Biological and medical sciences Dimerization Medical sciences Neuropharmacology Pharmacology. Drug treatments Polyphenol Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Stilbene Stilbenes - chemistry β-Amyloid peptide |
| title | New stilbene dimers against amyloid fibril formation |
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