New stilbene dimers against amyloid fibril formation

Two new stilbene dimers could be efficient fibril inhibitors in Alzheimer’s disease: scirpusin A and ε-viniferin glucoside. Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-β peptide (Aβ) aggregation. Results of stilbene monomer derivatives indica...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-06, Vol.20 (11), p.3441-3443
Hauptverfasser:	Rivière, Céline, Papastamoulis, Yorgos, Fortin, Pierre-Yves, Delchier, Nicolas, Andriamanarivo, Soahary, Waffo-Teguo, Pierre, Kapche, Gilbert D.W.F., Amira-Guebalia, H., Delaunay, Jean-Claude, Mérillon, Jean-Michel, Richard, Tristan, Monti, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyloid - chemistry Biological and medical sciences Dimerization Medical sciences Neuropharmacology Pharmacology. Drug treatments Polyphenol Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Stilbene Stilbenes - chemistry β-Amyloid peptide
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Zusammenfassung:	Two new stilbene dimers could be efficient fibril inhibitors in Alzheimer’s disease: scirpusin A and ε-viniferin glucoside. Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-β peptide (Aβ) aggregation. Results of stilbene monomer derivatives indicated that interaction with resveratrol and piceid was specific. Concerning oligomers, scirpusin A and ε-viniferin glucoside demonstrated a strong inhibition of the aggregation process.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.09.074