Binaphthyl-Based Dicationic Peptoids with Therapeutic Potential

Binaphthyl-Based Dicationic Peptoids with Therapeutic Potential

Superbugs stalled! Two newly designed synthetic dicationic peptoids (see one example; red O, blue N, green Cl) show promising in vitro bactericidal activity against a range of Gram‐positive pathogens, including organisms resistant to vancomycin, methicillin, and linezolid, with only slow development...

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Veröffentlicht in:Angewandte Chemie International Edition 2010-01, Vol.49 (3), p.537-540
Hauptverfasser: Bremner, John B., Keller, Paul A., Pyne, Stephen G., Boyle, Timothy P., Brkic, Zinka, David, Dorothy M., Garas, Adel, Morgan, Jody, Robertson, Mark, Somphol, Kittiya, Miller, Michael H., Howe, Adam S., Ambrose, Paul, Bhavnani, Sujata, Fritsche, Thomas R., Biedenbach, Douglas J., Jones, Ronald N., Buckheit Jr, Robert W., Watson, Karen M., Baylis, Dean, Coates, Jonathan A., Deadman, John, Jeevarajah, Dharshini, McCracken, Andrea, Rhodes, David I.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Anti-Infective Agents - therapeutic use
antibiotics
Bacteria - drug effects
biological activity
bioorganic chemistry
Cations
drug discovery
Molecular Structure
Naphthalenes - chemistry
peptidomimetics
Peptoids - chemical synthesis
Peptoids - chemistry
Peptoids - therapeutic use
Vancomycin - pharmacology
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Beschreibung
Zusammenfassung:Superbugs stalled! Two newly designed synthetic dicationic peptoids (see one example; red O, blue N, green Cl) show promising in vitro bactericidal activity against a range of Gram‐positive pathogens, including organisms resistant to vancomycin, methicillin, and linezolid, with only slow development of resistance. Moreover their potency is maintained in vivo.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200904392