Novel chromosomal translocations in multiple myeloma: t(13;16)(q14;q24) and t(1;15)(q10;q26)

Summary Multiple myeloma (MM) is a malignant plasma cell disorder that involves multiple genetic abnormalities. Chimeric transcription factors, created by gene fusion as a result of chromosomal translocations, have been implicated in the pathogenesis of the disease. Here, we report the conventional...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of laboratory hematology 2007-06, Vol.29 (3), p.215-220
Hauptverfasser:	AKALIN, I., KUTLAY, N. Y., ILHAN, O., TUKUN, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 13 - genetics Chromosomes, Human, Pair 15 - genetics Chromosomes, Human, Pair 16 - genetics Humans i(q10) In Situ Hybridization, Fluorescence inv(p11q13) Male Middle Aged Multiple myeloma Multiple Myeloma - genetics t(13 16) t(1 15) translocation Translocation, Genetic - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Multiple myeloma (MM) is a malignant plasma cell disorder that involves multiple genetic abnormalities. Chimeric transcription factors, created by gene fusion as a result of chromosomal translocations, have been implicated in the pathogenesis of the disease. Here, we report the conventional cytogenetic analysis of a MM patient that showed a complex set of novel chromosomal rearrangements, including t(13;16)(q14;q24) and t(1;15)(q10;q26). This is probably the result of fusion of previously known genes, and would contribute to prognostic significance of the disease.
ISSN:	1751-5521 1751-553X
DOI:	10.1111/j.1751-553X.2006.00837.x