2-Aryl-3-(1H-Azol-1-yl)-1H-Indole Derivatives: A New Class of Antimycobacterial Compounds - Conventional Heating in Comparison with MW-Assisted Synthesis

2-Aryl-3-(1H-Azol-1-yl)-1H-Indole Derivatives: A New Class of Antimycobacterial Compounds - Conventional Heating in Comparison with MW-Assisted Synthesis

2‐Aryl‐3‐(1H‐imidazol‐1‐yl and 1H‐1,2,4‐triazol‐1‐yl)‐1H‐indole derivatives were synthesized and tested for their in‐vitro antifungal and antimycobacterial activities. These indole derivatives were devoid of antifungal activity against the tested strains of Candida spp. Yet, they exhibited an intere...

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Veröffentlicht in:Archiv der Pharmazie (Weinheim) 2009-12, Vol.342 (12), p.716-722
Hauptverfasser: Zampieri, Daniele, Mamolo, Maria Grazia, Laurini, Erik, Scialino, Giuditta, Banfi, Elena, Vio, Luciano
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Antifungal activity
Antifungal Agents - chemical synthesis
Antifungal Agents - pharmacology
Antimycobacterial activity
Candida
Candida - drug effects
Chemistry, Pharmaceutical - methods
Indole
Indoles - chemical synthesis
Indoles - pharmacology
Microbial Sensitivity Tests
Molecular Structure
MW-assisted synthesis
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Structure-Activity Relationship
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Zusammenfassung:2‐Aryl‐3‐(1H‐imidazol‐1‐yl and 1H‐1,2,4‐triazol‐1‐yl)‐1H‐indole derivatives were synthesized and tested for their in‐vitro antifungal and antimycobacterial activities. These indole derivatives were devoid of antifungal activity against the tested strains of Candida spp. Yet, they exhibited an interesting antitubercular activity against Mycobacterium tuberculosis reference strain H37Rv.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.200900031