The effect of ionomycin on calcium fluxes in sarcoplasmic reticulum vesicles and liposomes

Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M. The effect is due to an increase in the Ca2+ permeability of the membrane which is also observed on liposomes...

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Veröffentlicht in:	The Journal of biological chemistry 1979-07, Vol.254 (14), p.6229-6231
Hauptverfasser:	Beeler, T J, Jona, I, Martonosi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals Biological Transport, Active - drug effects Calcium - metabolism Ethers - pharmacology Ionophores - pharmacology Kinetics Liposomes Microsomes - metabolism Muscles - metabolism Oxalates - metabolism Rabbits Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism
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Beschreibung
Zusammenfassung:	Ionomycin, a recently discovered calcium ionophore, inhibits the ATP-dependent active Ca2+ transport of rabbit sarcoplasmic reticulum vesicles at concentrations as low as 10(-8) to 10(-6) M. The effect is due to an increase in the Ca2+ permeability of the membrane which is also observed on liposomes. The inhibition of Ca2+ uptake is accompanied by an increase in the Ca2+-sensitive ATPase activity of sarcoplasmic reticulum vesicles.
ISSN:	0021-9258 1083-351X
DOI:	10.1016/S0021-9258(18)50350-1