Gas chromatographic determination of glibenclamide in plasma
A gas-chromatographic method for glibenclamide determination in plasma is described. It involves derivatization of the drug with dinitrofluorobenzene and the use of an electron-capture detector. The quantitative evaluation is performed using tolbutamide as internal standard. Characteristics and spec...
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| Veröffentlicht in: | Clinica chimica acta 1979-04, Vol.93 (2), p.195-198 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | A gas-chromatographic method for glibenclamide determination in plasma is described.
It involves derivatization of the drug with dinitrofluorobenzene and the use of an electron-capture detector. The quantitative evaluation is performed using tolbutamide as internal standard.
Characteristics and specificity of the method for the principal metabolite of glibenclamide are examined. |
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| ISSN: | 0009-8981 1873-3492 |
| DOI: | 10.1016/0009-8981(79)90088-3 |