Ghrelin: more than endogenous growth hormone secretagogue

Ghrelin: more than endogenous growth hormone secretagogue

Since its discovery 10 years ago, intensive research has been performed on ghrelin. The significance of ghrelin as a growth hormone–releasing hormone, appetite regulator, energy conservator, and sympathetic nerve suppressor has now been well established. In this review, we summarize recent topics on...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2010-07, Vol.1200 (1), p.140-148
Hauptverfasser: Kojima, Masayasu, Kangawa, Kenji
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Appetite - physiology
appetite regulation
Energy conservation
Energy Metabolism - physiology
ghrelin
Ghrelin - physiology
growth hormone releasing
Growth Hormone-Releasing Hormone - physiology
Growth hormones
Hormones
Mice
Mice, Knockout
Mice, Transgenic
Precursors
Protease
Regulators
Rodents
Suppressors
Transgenic
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Beschreibung
Zusammenfassung:Since its discovery 10 years ago, intensive research has been performed on ghrelin. The significance of ghrelin as a growth hormone–releasing hormone, appetite regulator, energy conservator, and sympathetic nerve suppressor has now been well established. In this review, we summarize recent topics on ghrelin, such as the processing protease of the ghrelin precursor, ghrelin O‐acyl transaferase, ghrelin knockout and transgenic mice, and the molecular mechanism of ghrelin's orexigenesis.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2010.05516.x