Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors
A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)- S- 21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction . A series of heterocyclic cy...
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010-05, Vol.20 (9), p.2809-2812 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-
S-
21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction
.
A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (
+)-
S-
21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction. |
---|---|
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2010.03.059 |