Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors

A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)- S- 21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction . A series of heterocyclic cy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry letters 2010-05, Vol.20 (9), p.2809-2812
Hauptverfasser: Sabatucci, Joseph P., Mahaney, Paige E., Leiter, Jennifer, Johnston, Grace, Burroughs, Kevin, Cosmi, Scott, Zhang, Yingru, Ho, Douglas, Deecher, Darlene C., Trybulski, Eugene
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)- S- 21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction . A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified ( +)- S- 21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2010.03.059