Artificial diiron proteins: From structure to function

Artificial diiron proteins: From structure to function

De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the desi...

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Veröffentlicht in:Biopolymers 2005, Vol.80 (2-3), p.264-278
Hauptverfasser: Calhoun, Jennifer R., Nastri, Flavia, Maglio, Ornella, Pavone, Vincenzo, Lombardi, Angela, DeGrado, William F.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Catalytic Domain
computational protein design
de novo protein design
diiron protein
Dimerization
Iron - chemistry
metalloprotein
Metalloproteins - chemical synthesis
Metalloproteins - chemistry
Models, Molecular
Molecular Sequence Data
Protein Conformation
Protein Structure, Quaternary
Static Electricity
structure
Thermodynamics
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Zusammenfassung:De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins. © 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2005
ISSN:0006-3525
1097-0282
DOI:10.1002/bip.20230