Reliability of salivary cortisol assessments in cocaine dependent individuals

The aim of this study was to assess the reliability of salivary cortisol as a measure of hypothalmic–pituitary–adrenal (HPA) axis function in cocaine dependent individuals. Saliva and total plasma samples were collected from 49 abusers on 3 testing days in the morning, across eight time points per d...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2006-09, Vol.20 (5), p.650-655
Hauptverfasser:	Fox, H. C., Wilker, E. H., Kreek, M. J., Sinha, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Adult Biological and medical sciences Blood Specimen Collection Cocaine Cocaine-Related Disorders - diagnosis Cocaine-Related Disorders - metabolism Cortisol Drug addictions Drug addicts Evaluation Female Hormones Humans Hydrocortisone Hydrocortisone - analysis Hydrocortisone - blood Hydrocortisone - metabolism Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - physiology Male Medical sciences Menstrual Cycle - metabolism Middle Aged Neuropharmacology Pharmacology. Drug treatments Pituitary Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Reproducibility of Results Saliva Saliva - chemistry Sex Characteristics Specimen Handling Testing Toxicology
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Beschreibung
Zusammenfassung:	The aim of this study was to assess the reliability of salivary cortisol as a measure of hypothalmic–pituitary–adrenal (HPA) axis function in cocaine dependent individuals. Saliva and total plasma samples were collected from 49 abusers on 3 testing days in the morning, across eight time points per day. Significant associations between saliva and plasma cortisol were observed across all time points collapsed across 3 days in both men and women. These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals.
ISSN:	0269-8811 1461-7285
DOI:	10.1177/0269881106063474