Hydrophilic-Hydrophobic Binary Systems of Poly(2-hydroxyethyl methacrylate) and Polycaprolactone. Part II: Degradation

Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels can be mechanically reinforced by the incorporation of a hydrophobic biodegradable polyester, polycaprolactone (PCL). The influence of PHEMA on the selective degradability of PCL in the modified hydrogels was investigated by hydrolysis, biodegradat...

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Veröffentlicht in:Journal of bioactive and compatible polymers 1994, Vol.9 (2), p.210-221
Hauptverfasser: Eschbach, Florence O., Huang, Samuel J., Cameron, J.A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels can be mechanically reinforced by the incorporation of a hydrophobic biodegradable polyester, polycaprolactone (PCL). The influence of PHEMA on the selective degradability of PCL in the modified hydrogels was investigated by hydrolysis, biodegradation and chemical degradation. The swelling of the PHEMA compo nent in hydrophilic reagents provided hydrolytic exposure to PCL domains. In hydrophobic reagents, the PHEMA component acted as a barrier that retarded the diffusion of hydrophobic acid or base into the network.
ISSN:0883-9115
1530-8030
DOI:10.1177/088391159400900206