Oxygen status model for the ventilatory and circulatory contribution to tissue oxygenation

The paper presents an oxygen status model (OSM) for simulation of major respiratory and circulatory malfunctions and the effect of ventilatory or hemodynamic medical intervention. The OSM includes a model of a ventilator and the human respiratory and circulatory systems, implemented as a causal probabilistic network (CPN). The CPN representation makes OSM able to consider uncertainties during simulation. OSM was tested as a simulation tool on two fictive cardiovascular or ventilatory disease states. The results demonstrate the potential of the OSM with respect to simulation of disease states and their treatments.