Kinetics of Pertussis Immune Responses to Tetanus-Diphtheria-Acellular Pertussis Vaccine in Health Care Personnel: Implications for Outbreak Control

We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adu...

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Veröffentlicht in:	Clinical infectious diseases 2009-08, Vol.49 (4), p.584-587
Hauptverfasser:	Kirkland, Kathryn B., Talbot, Elizabeth A., Decker, Michael D., Edwards, Kathryn M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Aged Antibodies Antibodies, Bacterial - blood Antigens Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Brief Reports Diphtheria Diphtheria toxoid Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Disease control Disease outbreaks Disease Outbreaks - prevention & control Diseases Ent and stomatologic bacterial diseases Female Fimbriae Health Personnel Human bacterial diseases Humans Immunization Immunization, Secondary Infectious diseases Kinetics Male Medical personnel Medical sciences Middle Aged Tetanus Vaccination Vaccines Whooping cough Whooping Cough - epidemiology Whooping Cough - prevention & control Young Adult
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Beschreibung
Zusammenfassung:	We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/603555