Distinct Cytokine Patterns in the Aqueous Humor of Children, Adolescents and Adults with Uveitis

Purpose: To determine the immune mediator profile in relation to age in the aqueous humor (AqH) of patients with uveitis. Methods: AqH of children, adolescents, and adults with uveitis was analyzed for 16 immune mediators. Results: No significant differences were found for IL-8, RANTES, and IP-10. The concentrations of the remaining 13 mediators were significant lower in adults compared with children and adolescents, except for IL-6, which was higher. Conclusions: Various immune mediators are present in higher concentrations in AqH of children and adolescents with different uveitis entities compared with that of adults, except IL-6, which was higher in adults.