Relation of HVH-II to Carcinoma of the Cervix
An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 months, the equivalent of 60 human years, there wa...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1979-05, Vol.53 (5), p.553-558 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 53 |
| creator | TOBIN, S M FISH, E N COOTER, N B.E PAPSIN, F R |
| description | An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 months, the equivalent of 60 human years, there was no evidence of anaplasia. These results are considered in relation to the role of HVH-II as an initiator in the multistep process leading to cervical carcinoma. |
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Although the study spanned a period of 30 months, the equivalent of 60 human years, there was no evidence of anaplasia. These results are considered in relation to the role of HVH-II as an initiator in the multistep process leading to cervical carcinoma.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 440666</identifier><language>eng</language><publisher>United States: The American College of Obstetricians and Gynecologists</publisher><subject>Animals ; Cervix Uteri - pathology ; Disease Models, Animal ; Female ; Herpes Simplex - complications ; Herpes Simplex - pathology ; Hyperplasia ; Metaplasia ; Precancerous Conditions ; Rats ; Uterine Cervical Diseases - complications ; Uterine Cervical Diseases - pathology ; Uterine Cervical Dysplasia - etiology ; Uterine Cervical Neoplasms - etiology ; Uterine Cervical Neoplasms - pathology ; Vaginal Diseases - complications ; Vaginal Diseases - pathology</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1979-05, Vol.53 (5), p.553-558</ispartof><rights>1979 The American College of Obstetricians and Gynecologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/440666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOBIN, S M</creatorcontrib><creatorcontrib>FISH, E N</creatorcontrib><creatorcontrib>COOTER, N B.E</creatorcontrib><creatorcontrib>PAPSIN, F R</creatorcontrib><title>Relation of HVH-II to Carcinoma of the Cervix</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 months, the equivalent of 60 human years, there was no evidence of anaplasia. These results are considered in relation to the role of HVH-II as an initiator in the multistep process leading to cervical carcinoma.</description><subject>Animals</subject><subject>Cervix Uteri - pathology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - pathology</subject><subject>Hyperplasia</subject><subject>Metaplasia</subject><subject>Precancerous Conditions</subject><subject>Rats</subject><subject>Uterine Cervical Diseases - complications</subject><subject>Uterine Cervical Diseases - pathology</subject><subject>Uterine Cervical Dysplasia - etiology</subject><subject>Uterine Cervical Neoplasms - etiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Vaginal Diseases - complications</subject><subject>Vaginal Diseases - pathology</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotUMtOwzAQtBCvUvgDDjlxs7SOHSc5oghopEpICBC3aONu1IBTFzuh8Pe4ak-7OzNazcwJm4kilzyV8uOUzQDSkueFUpfsKoRPABC6lBfsXCnQWs8YfyGLY-82ieuSxfuC13UyuqRCb_qNG3APj2tKKvI__e81O-vQBro5zjl7e3x4rRZ8-fxUV_dLvk0zUDwVkrSRK8yhLRFVh_nKILYdtZCVLRAaQXGJXtBoY7AouqITUsu00CBIztnd4e_Wu--JwtgMfTBkLW7ITaHJVaYlSBmFt0fh1A60ara-H9D_NYd4kVYHeufsSD582WlHvlkT2nHdxDZAR8NclHkJWbz4HlLyH--gWqc</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>TOBIN, S M</creator><creator>FISH, E N</creator><creator>COOTER, N B.E</creator><creator>PAPSIN, F R</creator><general>The American College of Obstetricians and Gynecologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197905</creationdate><title>Relation of HVH-II to Carcinoma of the Cervix</title><author>TOBIN, S M ; FISH, E N ; COOTER, N B.E ; PAPSIN, F R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2504-213e6c3da70b9aa4fa7dcaabfeb059b0eac1e59b169ac6cca88f8f136328601e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Cervix Uteri - pathology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Herpes Simplex - complications</topic><topic>Herpes Simplex - pathology</topic><topic>Hyperplasia</topic><topic>Metaplasia</topic><topic>Precancerous Conditions</topic><topic>Rats</topic><topic>Uterine Cervical Diseases - complications</topic><topic>Uterine Cervical Diseases - pathology</topic><topic>Uterine Cervical Dysplasia - etiology</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Vaginal Diseases - complications</topic><topic>Vaginal Diseases - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOBIN, S M</creatorcontrib><creatorcontrib>FISH, E N</creatorcontrib><creatorcontrib>COOTER, N B.E</creatorcontrib><creatorcontrib>PAPSIN, F R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOBIN, S M</au><au>FISH, E N</au><au>COOTER, N B.E</au><au>PAPSIN, F R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of HVH-II to Carcinoma of the Cervix</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1979-05</date><risdate>1979</risdate><volume>53</volume><issue>5</issue><spage>553</spage><epage>558</epage><pages>553-558</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><abstract>An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. 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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1979-05, Vol.53 (5), p.553-558 |
| issn | 0029-7844 1873-233X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74563033 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Cervix Uteri - pathology Disease Models, Animal Female Herpes Simplex - complications Herpes Simplex - pathology Hyperplasia Metaplasia Precancerous Conditions Rats Uterine Cervical Diseases - complications Uterine Cervical Diseases - pathology Uterine Cervical Dysplasia - etiology Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - pathology Vaginal Diseases - complications Vaginal Diseases - pathology |
| title | Relation of HVH-II to Carcinoma of the Cervix |
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