Relation of HVH-II to Carcinoma of the Cervix

An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 months, the equivalent of 60 human years, there wa...

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Veröffentlicht in:	Obstetrics and gynecology (New York. 1953) 1979-05, Vol.53 (5), p.553-558
Hauptverfasser:	TOBIN, S M, FISH, E N, COOTER, N B.E, PAPSIN, F R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cervix Uteri - pathology Disease Models, Animal Female Herpes Simplex - complications Herpes Simplex - pathology Hyperplasia Metaplasia Precancerous Conditions Rats Uterine Cervical Diseases - complications Uterine Cervical Diseases - pathology Uterine Cervical Dysplasia - etiology Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - pathology Vaginal Diseases - complications Vaginal Diseases - pathology
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Beschreibung
Zusammenfassung:	An animal model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia, and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 months, the equivalent of 60 human years, there was no evidence of anaplasia. These results are considered in relation to the role of HVH-II as an initiator in the multistep process leading to cervical carcinoma.
ISSN:	0029-7844 1873-233X