Is long-term virological response related to CCR5 32 deletion in HIV-1-infected patients started on highly active antiretroviral therapy?

Is long-term virological response related to CCR5 32 deletion in HIV-1-infected patients started on highly active antiretroviral therapy?

ObjectiveThe aim of the study was to determine whether the chemokine (C-C motif) receptor 5 (CCR5) 32 deletion is associated with long-term response to combination antiretroviral treatment (cART) in HIV-1-infected patients.MethodsThe genetic substudy of the Agence Nationale de Recherche sur le SIDA...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:HIV medicine 2010-04, Vol.11 (4), p.239-244
Hauptverfasser: Laurichesse, J-J, Taieb, A, Capoulade-Metay, C, Katlama, C, Villes, V, Drobacheff-Thiebaud, M-C, Raffi, F, Chene, G, Theodorou, I, Leport, C
Format: Artikel
Sprache:eng
Schlagworte:
Human immunodeficiency virus 1
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ObjectiveThe aim of the study was to determine whether the chemokine (C-C motif) receptor 5 (CCR5) 32 deletion is associated with long-term response to combination antiretroviral treatment (cART) in HIV-1-infected patients.MethodsThe genetic substudy of the Agence Nationale de Recherche sur le SIDA (ANRS) CO8 APROCO-COPILOTE cohort included 609 patients who started protease inhibitor-containing cART in 1997-1999. Patients were considered to have a sustained virological response if all plasma HIV RNA measurements in the period considered were
ISSN:1464-2662
DOI:10.1111/j.1468-1293.2009.00769.x