Modifications of dopac levels in the striatum and olfactory tubercles of the rat after muscimol
When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfact...
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| Veröffentlicht in: | Pharmacological research communications 1979, Vol.11 (1), p.55-59 |
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| container_title | Pharmacological research communications |
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| creator | Restelli, A. Zambotti, F. Vicentini, L. Zonta, N. Mantegazza, P. |
| description | When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfactory tubercles after both routes of administration. The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol. |
| doi_str_mv | 10.1016/S0031-6989(79)80098-3 |
| format | Article |
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The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol.</description><identifier>ISSN: 0031-6989</identifier><identifier>EISSN: 1879-2936</identifier><identifier>DOI: 10.1016/S0031-6989(79)80098-3</identifier><identifier>PMID: 424439</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Animals ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Injections, Intraperitoneal ; Injections, Intraventricular ; Male ; Muscimol - administration & dosage ; Muscimol - pharmacology ; Olfactory Bulb - drug effects ; Olfactory Bulb - metabolism ; Oxazoles - pharmacology ; Phenylacetates - metabolism ; Rats ; Time Factors</subject><ispartof>Pharmacological research communications, 1979, Vol.11 (1), p.55-59</ispartof><rights>1979 The Italian Pharmacological Society</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-53a268808ab0c479eaa6eac3e6d18a62006bbf7e5ec81a050de409d8ee1dfc6a3</citedby><cites>FETCH-LOGICAL-c359t-53a268808ab0c479eaa6eac3e6d18a62006bbf7e5ec81a050de409d8ee1dfc6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/424439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Restelli, A.</creatorcontrib><creatorcontrib>Zambotti, F.</creatorcontrib><creatorcontrib>Vicentini, L.</creatorcontrib><creatorcontrib>Zonta, N.</creatorcontrib><creatorcontrib>Mantegazza, P.</creatorcontrib><title>Modifications of dopac levels in the striatum and olfactory tubercles of the rat after muscimol</title><title>Pharmacological research communications</title><addtitle>Pharmacol Res Commun</addtitle><description>When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfactory tubercles after both routes of administration. The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Animals</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Muscimol - administration & dosage</subject><subject>Muscimol - pharmacology</subject><subject>Olfactory Bulb - drug effects</subject><subject>Olfactory Bulb - metabolism</subject><subject>Oxazoles - pharmacology</subject><subject>Phenylacetates - metabolism</subject><subject>Rats</subject><subject>Time Factors</subject><issn>0031-6989</issn><issn>1879-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1L7TAQxYP4df34DxSykvcW1aRp02QlIr6noLhQ12GaTDHSNtckFfzv7b1X3LoahnPOHOZHyCln55xxefHEmOCF1Er_afRfxZhWhdgiC64aXZRayG2y-LHsk4OU3ua1lJztkd2qrCqhF8Q8BOc7byH7MCYaOurCEizt8QP7RP1I8yvSlKOHPA0URkdD34HNIX7SPLUYbY_r3MoXIVPoMkY6TMn6IfRHZKeDPuHx9zwkL_9unq9vi_vH_3fXV_eFFbXORS2glEoxBS2zVaMRQCJYgdJxBbJkTLZt12CNVnFgNXNYMe0UInedlSAOydnm7jKG9wlTNoNPFvseRgxTMk1Vc1nqejbWG6ONIaWInVlGP0D8NJyZFVez5mpW0EyjzZqrEXPu5Ltgagd0P6kNyFm-3MgzNfzwGM38P44WnY9os3HB_1LwBVQriYE</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Restelli, A.</creator><creator>Zambotti, F.</creator><creator>Vicentini, L.</creator><creator>Zonta, N.</creator><creator>Mantegazza, P.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Modifications of dopac levels in the striatum and olfactory tubercles of the rat after muscimol</title><author>Restelli, A. ; Zambotti, F. ; Vicentini, L. ; Zonta, N. ; Mantegazza, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-53a268808ab0c479eaa6eac3e6d18a62006bbf7e5ec81a050de409d8ee1dfc6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Animals</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Muscimol - administration & dosage</topic><topic>Muscimol - pharmacology</topic><topic>Olfactory Bulb - drug effects</topic><topic>Olfactory Bulb - metabolism</topic><topic>Oxazoles - pharmacology</topic><topic>Phenylacetates - metabolism</topic><topic>Rats</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Restelli, A.</creatorcontrib><creatorcontrib>Zambotti, F.</creatorcontrib><creatorcontrib>Vicentini, L.</creatorcontrib><creatorcontrib>Zonta, N.</creatorcontrib><creatorcontrib>Mantegazza, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Restelli, A.</au><au>Zambotti, F.</au><au>Vicentini, L.</au><au>Zonta, N.</au><au>Mantegazza, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modifications of dopac levels in the striatum and olfactory tubercles of the rat after muscimol</atitle><jtitle>Pharmacological research communications</jtitle><addtitle>Pharmacol Res Commun</addtitle><date>1979</date><risdate>1979</risdate><volume>11</volume><issue>1</issue><spage>55</spage><epage>59</epage><pages>55-59</pages><issn>0031-6989</issn><eissn>1879-2936</eissn><abstract>When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfactory tubercles after both routes of administration. The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>424439</pmid><doi>10.1016/S0031-6989(79)80098-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6989 |
| ispartof | Pharmacological research communications, 1979, Vol.11 (1), p.55-59 |
| issn | 0031-6989 1879-2936 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Injections, Intraperitoneal Injections, Intraventricular Male Muscimol - administration & dosage Muscimol - pharmacology Olfactory Bulb - drug effects Olfactory Bulb - metabolism Oxazoles - pharmacology Phenylacetates - metabolism Rats Time Factors |
| title | Modifications of dopac levels in the striatum and olfactory tubercles of the rat after muscimol |
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