Modifications of dopac levels in the striatum and olfactory tubercles of the rat after muscimol

Modifications of dopac levels in the striatum and olfactory tubercles of the rat after muscimol

When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfact...

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Veröffentlicht in:Pharmacological research communications 1979, Vol.11 (1), p.55-59
Hauptverfasser: Restelli, A., Zambotti, F., Vicentini, L., Zonta, N., Mantegazza, P.
Format: Artikel
Sprache:eng
Schlagworte:
3,4-Dihydroxyphenylacetic Acid - metabolism
Animals
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Injections, Intraperitoneal
Injections, Intraventricular
Male
Muscimol - administration & dosage
Muscimol - pharmacology
Olfactory Bulb - drug effects
Olfactory Bulb - metabolism
Oxazoles - pharmacology
Phenylacetates - metabolism
Rats
Time Factors
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Zusammenfassung:When muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfactory tubercles after both routes of administration. The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol.
ISSN:0031-6989
1879-2936
DOI:10.1016/S0031-6989(79)80098-3