Epidural morphine in treatment of pain

Epidural injections of a 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid s...

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Veröffentlicht in:	The Lancet (British edition) 1979-03, Vol.1 (8115), p.527-529
Hauptverfasser:	Behar, M, Magora, F, Olshwang, D, Davidson, J T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Aged Analgesia - methods Chronic Disease Epidural Space - drug effects Female Fractures, Bone - complications Humans Injections Male Middle Aged Morphine - administration & dosage Pain - etiology Pain, Intractable - drug therapy Pain, Postoperative - drug therapy Receptors, Opioid - drug effects Substantia Gelatinosa - drug effects
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Zusammenfassung:	Epidural injections of a 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid space and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior-horn cells of the spinal cord.
ISSN:	0140-6736