Anti-tumour effect of chlorambucil-antibody complexes in a murine melanoma system

An anti-serum against a transplantable murine melanoma (Harding Passey melanoma; HPM) was raised in rabbits. The IgG fraction of the anti-serum was non-covalently linked to chlorambucil. The chlorambucil-antibody complex was tested in BALB/c mice injected i.p. with HMP cells. The complex had conside...

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Veröffentlicht in:	European journal of cancer 1979, Vol.15 (1), p.69-75
Hauptverfasser:	Dullens, H.F., De Weger, R.A., Vennegoor, C., Den Otter, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - administration & dosage Cell Survival - drug effects Cells, Cultured Chlorambucil - administration & dosage Chlorambucil - pharmacology Chlorambucil - therapeutic use Female Immune Sera Immunoglobulin G - administration & dosage Male Melanoma - drug therapy Mice Mice, Inbred BALB C Mice, Inbred DBA Neoplasms, Experimental - drug therapy
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Zusammenfassung:	An anti-serum against a transplantable murine melanoma (Harding Passey melanoma; HPM) was raised in rabbits. The IgG fraction of the anti-serum was non-covalently linked to chlorambucil. The chlorambucil-antibody complex was tested in BALB/c mice injected i.p. with HMP cells. The complex had considerably more anti-tumour effect than the unlinked components.
ISSN:	0014-2964
DOI:	10.1016/0014-2964(79)90207-X