Propranolol, chlorpromazine and platelet membrane: A fluorescence study of the drug-membrane interaction

The binding of propranolol 1 μM (PRO) and chlorpromazine 35 μM (CPZ) was studied on liposomes of the main platelet phospholipids: phosphatidylcholine (PC), phosphatidylethanolamine (PE) phosphatidylserine (PS), phosphatidylinositol (PI) and sphingomyelin (SPH), on the pool of platelet extracted phos...

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Veröffentlicht in:	Thrombosis research 1979, Vol.14 (1), p.15-22
Hauptverfasser:	Dachary-Prigent, J., Dufourcq, J., Lussan, C., Boisseau, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Blood Platelets - drug effects Cattle Cell Membrane - physiology Chickens Chlorpromazine - pharmacology Humans Phosphatidylcholines - physiology Phosphatidylethanolamines - physiology Phosphatidylinositols - physiology Phosphatidylserines - physiology Phospholipids - physiology Propranolol - pharmacology Spectrometry, Fluorescence Sphingomyelins - physiology Swine
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Zusammenfassung:	The binding of propranolol 1 μM (PRO) and chlorpromazine 35 μM (CPZ) was studied on liposomes of the main platelet phospholipids: phosphatidylcholine (PC), phosphatidylethanolamine (PE) phosphatidylserine (PS), phosphatidylinositol (PI) and sphingomyelin (SPH), on the pool of platelet extracted phospholipids (PPL) and on platelet membrane (PM) by means of the fluorescence emission properties of the two drugs. We concluded that PRO and CPZ bind preferentially with PS and PI which are localized in the inner bilayer of the platelet membrane. This result is the first experimental evidence of the suggestion of many authors that cationic drugs bind to negative phospholipids.
ISSN:	0049-3848 1879-2472
DOI:	10.1016/0049-3848(79)90020-3