The functional effect of epigallocatechin gallate on ischemic stroke in rats

We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated o...

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Veröffentlicht in:	Acta neurobiologiae experimentalis 2010-01, Vol.70 (1), p.40-46
Hauptverfasser:	Lim, Seong Hoon, Kim, Han Seung, Kim, Young Kook, Kim, Tae Min, Im, Sun, Chung, Myung Eun, Hong, Bo Young, Ko, Young Jin, Kim, Hye Won, Lee, Jong In
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Behavior, Animal - physiology Brain Infarction - drug therapy Brain Infarction - etiology Brain Infarction - pathology Catechin - analogs & derivatives Catechin - therapeutic use Disease Models, Animal Hindlimb - physiopathology Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Male Neuroprotective Agents - therapeutic use Rats Rats, Sprague-Dawley Sensory Gating - drug effects Statistics, Nonparametric
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Zusammenfassung:	We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated on days 1, 5, 10, and 14 after ischemia, using a modified sticky-tape test and the percentage weight borne on the paretic leg. Infarct volume did not differ between the EGCG-treated and MCAO control groups. Compared with the MCAO control group, the EGCG-treated group showed improved forelimb function and had normal function by day 10 (P
ISSN:	0065-1400 1689-0035
DOI:	10.55782/ane-2010-1772