In vitro studies on microphage functions in chronic pyoderma vegetans
The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans a...
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| Veröffentlicht in: | Archives of Dermatological Research 1978-01, Vol.263 (1), p.97-104 |
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| container_title | Archives of Dermatological Research |
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| creator | Djawari, D Hornstein, O P |
| description | The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus aureus, and a weakness of the intracellular killing of these microorganisms. However, the NADH-dependent oxidase activity appeared to be intact. No defect was found in the specific cellular or humoral immune system in either patient. |
| doi_str_mv | 10.1007/BF00446859 |
| format | Article |
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The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus aureus, and a weakness of the intracellular killing of these microorganisms. However, the NADH-dependent oxidase activity appeared to be intact. 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The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus aureus, and a weakness of the intracellular killing of these microorganisms. However, the NADH-dependent oxidase activity appeared to be intact. No defect was found in the specific cellular or humoral immune system in either patient.</description><subject>Adult</subject><subject>Candida albicans - immunology</subject><subject>Chemotaxis, Leukocyte</subject><subject>Chronic Disease</subject><subject>Humans</subject><subject>Male</subject><subject>NADH Tetrazolium Reductase - metabolism</subject><subject>Neutrophils - enzymology</subject><subject>Nitroblue Tetrazolium</subject><subject>Phagocytes - physiology</subject><subject>Phagocytosis</subject><subject>Pyoderma - immunology</subject><subject>Pyoderma - microbiology</subject><subject>Pyoderma - pathology</subject><subject>Staphylococcus aureus - immunology</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LAzEQhoP4VWovnj3k5EFYzVc3yVFLq4WCFwVvS5rMtpFuUpPdQv-9Ky16dQ4zDDy88D4IXVNyTwmRD08zQoQo1VifoAEVnBWk1B-naEC4IAUvdXmJRjl_kn4kEYzIC3TOS94_AzSdB7zzbYo4t53zkHEMuPE2xe3arADXXbCtjyFjH7Bdpxi8xdt9dJAag3ewgtaEfIXOarPJMDreIXqfTd8mL8Xi9Xk-eVwUljHZFsoJulxqVfbLaapprVTNnSoZJcrVXAPwsWFUMMMJUGWd0sD6dkZYzTTwIbo95G5T_Oogt1Xjs4XNxgSIXa6kEJJwKf8BMjlmSvTg3QHsG-ecoK62yTcm7StKqh-91Z_eHr45pnbLBtwvepDJvwGUZXOF</recordid><startdate>197801</startdate><enddate>197801</enddate><creator>Djawari, D</creator><creator>Hornstein, O P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197801</creationdate><title>In vitro studies on microphage functions in chronic pyoderma vegetans</title><author>Djawari, D ; Hornstein, O P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c227t-8d41bb986bb9d9191f88f3d862108df39ee35a2142a30e18cd89e2004a4c929e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Candida albicans - immunology</topic><topic>Chemotaxis, Leukocyte</topic><topic>Chronic Disease</topic><topic>Humans</topic><topic>Male</topic><topic>NADH Tetrazolium Reductase - metabolism</topic><topic>Neutrophils - enzymology</topic><topic>Nitroblue Tetrazolium</topic><topic>Phagocytes - physiology</topic><topic>Phagocytosis</topic><topic>Pyoderma - immunology</topic><topic>Pyoderma - microbiology</topic><topic>Pyoderma - pathology</topic><topic>Staphylococcus aureus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Djawari, D</creatorcontrib><creatorcontrib>Hornstein, O P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Djawari, D</au><au>Hornstein, O P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro studies on microphage functions in chronic pyoderma vegetans</atitle><jtitle>Archives of Dermatological Research</jtitle><addtitle>Arch Dermatol Res</addtitle><date>1978-01</date><risdate>1978</risdate><volume>263</volume><issue>1</issue><spage>97</spage><epage>104</epage><pages>97-104</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus aureus, and a weakness of the intracellular killing of these microorganisms. However, the NADH-dependent oxidase activity appeared to be intact. No defect was found in the specific cellular or humoral immune system in either patient.</abstract><cop>Germany</cop><pmid>363070</pmid><doi>10.1007/BF00446859</doi><tpages>8</tpages></addata></record> |
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| ispartof | Archives of Dermatological Research, 1978-01, Vol.263 (1), p.97-104 |
| issn | 0340-3696 1432-069X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Candida albicans - immunology Chemotaxis, Leukocyte Chronic Disease Humans Male NADH Tetrazolium Reductase - metabolism Neutrophils - enzymology Nitroblue Tetrazolium Phagocytes - physiology Phagocytosis Pyoderma - immunology Pyoderma - microbiology Pyoderma - pathology Staphylococcus aureus - immunology |
| title | In vitro studies on microphage functions in chronic pyoderma vegetans |
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