Antimicrobial treatment for early, limited Mycobacterium ulcerans infection: a randomised controlled trial

Summary Background Surgical debridement was the standard treatment for Mycobacterium ulcerans infection (Buruli ulcer disease) until WHO issued provisional guidelines in 2004 recommending treatment with antimicrobial drugs (streptomycin and rifampicin) in addition to surgery. These recommendations w...

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Veröffentlicht in:	The Lancet (British edition) 2010-02, Vol.375 (9715), p.664-672
Hauptverfasser:	Nienhuis, Willemien A, MD, Stienstra, Ymkje, MD, Thompson, William A, MD, Awuah, Peter C, MD, Abass, K Mohammed, Tuah, Wilson, Awua-Boateng, Nana Yaa, Ampadu, Edwin O, MD, Siegmund, Vera, PhD, Schouten, Jan P, MSc, Adjei, Ohene, Prof, Bretzel, Gisela, MD, van der Werf, Tjip S, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscesses Administration, Oral Adolescent Adult Anti-Bacterial Agents - therapeutic use Antimicrobial agents Bacterial diseases Biological and medical sciences Buruli Ulcer - diagnosis Buruli Ulcer - drug therapy Child Clarithromycin - therapeutic use Colleges & universities Committees Design Disease Drug Administration Schedule Drug Therapy, Combination Endpoint Determination Female Follow-Up Studies General aspects Ghana Health services Human bacterial diseases Humans Infectious diseases Injections, Intramuscular Internal Medicine Leprostatic Agents - therapeutic use Lesions Male Medical sciences Mycobacterium ulcerans Mycobacterium ulcerans - drug effects Mycobacterium ulcerans - isolation & purification Observational studies Patients Rifampin - therapeutic use Statistics, Nonparametric Streptomycin - therapeutic use Studies Teaching hospitals Time Factors Tissues Treatment Outcome Tuberculosis and atypical mycobacterial infections Young Adult
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Zusammenfassung:	Summary Background Surgical debridement was the standard treatment for Mycobacterium ulcerans infection (Buruli ulcer disease) until WHO issued provisional guidelines in 2004 recommending treatment with antimicrobial drugs (streptomycin and rifampicin) in addition to surgery. These recommendations were based on observational studies and a small pilot study with microbiological endpoints. We investigated the efficacy of two regimens of antimicrobial treatment in early-stage M ulcerans infection. Methods In this parallel, open-label, randomised trial undertaken in two sites in Ghana, patients were eligible for enrolment if they were aged 5 years or older and had early (duration
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(09)61962-0