Circulating 25-Hydroxyvitamin D and Risk of Kidney Cancer

Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between cir...

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Veröffentlicht in:American journal of epidemiology 2010-07, Vol.172 (1), p.47-57
Hauptverfasser: Gallicchio, Lisa, Moore, Lee E., Stevens, Victoria L., Ahn, Jiyoung, Albanes, Demetrius, Hartmuller, Virginia, Setiawan, V. Wendy, Helzlsouer, Kathy J., Yang, Gong, Xiang, Yong-Bing, Shu, Xiao-Ou, Snyder, Kirk, Weinstein, Stephanie J., Yu, Kai, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Cai, Qiuyin, Campbell, David S., Chen, Yu, Chow, Wong-Ho, Horst, Ronald L., Kolonel, Laurence N., McCullough, Marjorie L., Purdue, Mark P., Koenig, Karen L.
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Sprache:eng
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Zusammenfassung:Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12, 0.85) with 25(OH)D concentrations of ≥75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwq115