Role of Reduced Glutathione in the Amelioration of Nicotine-Induced Oxidative Stress

Nicotine, a major toxic component of cigarette smoke has been identified as a major risk factor for different diseases. This study investigates the role of reduce glutathione (GSH) against nicotine treated liver and kidney toxicity. Results showed that the application of 80 mg GSH per kg body weight...

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Veröffentlicht in:	Bulletin of environmental contamination and toxicology 2010-04, Vol.84 (4), p.385-389
Hauptverfasser:	Dey, S. K, Roy, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - analysis Aquatic Pollution Body weight Catalase - analysis Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Glutathione - pharmacology Kidney - drug effects Kidney - enzymology Kidneys Lactate Dehydrogenases - analysis Lipid Peroxidation - drug effects Liver Liver - drug effects Liver - enzymology Male Nicotine Nicotine - toxicity Oxidation Oxidative stress Oxidative Stress - drug effects Peroxidation Pollution Rats Rats, Wistar Risk factors Soil Science & Conservation Toxicity Waste Water Technology Water Management Water Pollution Control
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Beschreibung
Zusammenfassung:	Nicotine, a major toxic component of cigarette smoke has been identified as a major risk factor for different diseases. This study investigates the role of reduce glutathione (GSH) against nicotine treated liver and kidney toxicity. Results showed that the application of 80 mg GSH per kg body weight per day exert protective effect against nicotine-induced liver and kidney toxicity by modulating the biochemical marker enzyme LDH, lipid peroxidation and augmenting antioxidant defense system. To our knowledge, this is the first finding of this sort.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/s00128-010-9948-5