Fabrication and Characterization of Electrospun PLGA/MWNTs/ Hydroxyapatite Biocomposite Scaffolds for Bone Tissue Engineering
Biocomposite scaffolds of poly(lactic-co-glycolic acid) (PLGA), multiwalled carbon nanotubes (MWNTs), and hydroxyapatite (HA) nanoparticles were prepared ‘by electrospinning’ for bone tissue engineering. The structure, surface morphology, and some properties of these PLGA/MWNTs/ HA composites were e...
Gespeichert in:
Veröffentlicht in: | Journal of bioactive and compatible polymers 2010-05, Vol.25 (3), p.241-259 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Biocomposite scaffolds of poly(lactic-co-glycolic acid) (PLGA), multiwalled carbon nanotubes (MWNTs), and hydroxyapatite (HA) nanoparticles were prepared ‘by electrospinning’ for bone tissue engineering. The structure, surface morphology, and some properties of these PLGA/MWNTs/ HA composites were evaluated. Cultured bone marrow-derived mesenchymal stem cells (BMSCs) were seeded on the PLGA/MWNTs/HA scaffolds, and their attachment and proliferation were determined by scanning electron microscopy (SEM) and MTT assay, respectively. The composite scaffolds, a 3D nonwoven fabric construct mimicked the structure of the natural extracellular matrix. The average diameter of the PLGA/MWNTs/HA fibers increased with increasing HA content from 0.5% to 1.5% in the composites. The SEM and MTT results indicated good biocompatibility by the scaffolds, and that the attachment and proliferation of BMSCs were significantly increased in the PLGA/MWNTs/ 1.0%HA and PLGA/MWNTs/1.5%HA scaffolds compared with the PLGA control. These scaffolds, fabricated by electrospinning, indicate good potential for bone tissue engineering applications. |
---|---|
ISSN: | 0883-9115 1530-8030 |
DOI: | 10.1177/0883911509359486 |