Prognostic Impact of Protein Overexpression of the Proto-oncogene PIM-1 in Gastric Cancer

Background: PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor. Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma. Patients and Methods: Cancer tissues of 1...

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Veröffentlicht in:	Anticancer research 2009-11, Vol.29 (11), p.4451-4455
Hauptverfasser:	Warnecke-Eberz, Ute, Bollschweiler, Elfriede, Drebber, Uta, Metzger, Ralf, Baldus, Stephan E, Hölscher, Arnulf H, Mönig, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Female Humans Immunohistochemistry Male Middle Aged Prognosis Proto-Oncogene Proteins c-pim-1 - biosynthesis Proto-Oncogene Proteins c-pim-1 - metabolism Stomach Neoplasms - enzymology Stomach Neoplasms - pathology
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Zusammenfassung:	Background: PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor. Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma. Patients and Methods: Cancer tissues of 117 patients with potentially curative (R0) resections for gastric cancer were immunohistochemically stained for PIM-1. Results: Cytoplasmic immunoreactivity for PIM-1 in tumor (46%) was higher (p=0.003) compared to that in gastric glands (16%) and foveolae (1%). PIM-1 immunoreactivity in gastric carcinoma correlated with tumor grading (p
ISSN:	0250-7005 1791-7530