Effect of waveshape on iontophoretic drug delivery

Effect of waveshape on iontophoretic drug delivery

Iontophoresis is a form of transdermal delivery which forces poorly absorbed ionic drugs through the skin using a current to enhance penetration. To study the effect of waveshape on iontophoretic efficacy, a device was designed to synthesize several constant current waveforms including DC and pulsed...

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Bibliographische Detailangaben
Hauptverfasser: Zakzewski, C., Li, J.K.-J., Amory, D., Kalatzis-Manolakis, E.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Blood pressure
Current density
Drug delivery
Frequency
Hypertension
Immune system
Protocols
Rabbits
Skin
Vehicles
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Beschreibung
Zusammenfassung:Iontophoresis is a form of transdermal delivery which forces poorly absorbed ionic drugs through the skin using a current to enhance penetration. To study the effect of waveshape on iontophoretic efficacy, a device was designed to synthesize several constant current waveforms including DC and pulsed DC, and two novel iontophoretic waveforms - trapezoidal and biphasic pulsed DC. Each waveform was used to deliver an antihypertensive drug transdermally to acutely induced hypertensive rabbits.
DOI:10.1109/IEMBS.1993.978986